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Varför riktad probiotika ofta fungerar bättre än hundratals miljarder bakterier
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Why targeted probiotics often work better than hundreds of billions of bacteria

Probiotics have exploded in recent years. Shelves are filled with products boasting “50 billion bacteria,” “18 strains,” or “maximum diversity.” It sounds impressive. But in practice, it says very little about how the product actually works in the body.

More bacteria does not automatically mean a better effect

In my practice, I often meet people who have tried several different probiotics without really understanding why some help, others do nothing at all — and some actually make the stomach worse. More bloating. More gas. More discomfort. And often a feeling that they “did everything right” but still don’t feel better.

This is where I think the conversation around probiotics sometimes becomes a bit simplified.

Probiotics don’t work like a general health powder where more is always better. The effect is often strain-specific, dose-dependent, and very connected to the individual’s microbiome, immune system, and symptoms.

Gut health is not just about quantity. It’s about function. What the bacteria actually do. How they communicate with the body. How they affect the environment in the gut and the interaction with their host — that is, you.

Not all probiotics do the same thing

It’s easy to talk about “probiotics” as if all bacteria were the same. But different bacterial strains have completely different properties.

Some have been studied for IBS and bloating. Others affect the immune system or the gut barrier. Some produce metabolites that help the gut lining, while others seem to affect the nervous system via the gut-brain axis — the connection between the gut and the brain.

That is why two products with the same number of bacteria can have completely different effects. I therefore think you should be careful when choosing probiotics based on:

  • most billions of bacteria
  • most strains
  • marketing that sounds advanced

The most important thing is actually something completely different:

  • what symptoms you have
  • which function you want to influence
  • if the bacterial strains actually have research in that area

More is not always better

There is an idea that a “stronger” probiotic supplement is automatically better. I don’t always see that in reality.

A sensitive or stressed microbiome does not necessarily respond well to large amounts of bacteria at once. In some people - especially with IBS, histamine sensitivity, dysbiosis, or severe bloating - broad probiotic blends can sometimes create more symptoms instead of fewer.

That does not mean probiotics are wrong.

But it can mean that the choice has not been targeted enough.

Often I see better results when working more strategically:

  • right strain
  • right dose
  • right timing
  • right context

In some cases, it can also be valuable to do a stool analysis to understand what the microbiome actually looks like.

Do you need to increase species diversity? Support specific bacteria? Work with inflammation? Improve the environment for Bifidobacteria? Or is it more about the gut barrier, constipation, or recovery after antibiotics?

You can’t always guess.

Just like in nutrition in general, health is rarely about “taking the most.” It is more about understanding what the body needs right now.

Probiotics do not always colonize permanently

Another thing many miss is that probiotics do not always stay permanently in the gut. Many bacteria act more like temporary guests that influence the environment as they pass through.

But that does not make them any less interesting.

Certain bacterial strains can:

  • influence the production of short-chain fatty acids
  • support the gut lining
  • influence the immune system
  • compete with opportunistic bacteria
  • influence inflammation and neurotransmitters

At the same time, it is impossible to separate probiotics from the rest of the lifestyle.

The microbiome is constantly influenced by:

  • what we eat
  • how we sleep
  • stress levels
  • physical activity
  • circadian rhythm
  • antibiotics
  • the amount of fiber and polyphenols in the diet

That is why probiotics are rarely a quick fix. They are rather a tool in a larger ecosystem.

The most interesting thing right now: precision

What makes microbiome research so fascinating today is that it is increasingly moving towards precision.

The question begins to change from:
“Which probiotic is best?”

To:
“Which bacterial strain seems to help with this particular problem?”

That is an important difference.

We are also beginning to understand that people respond differently to the same bacteria. A strain that works wonderfully for one person can be completely neutral for someone else. The environment in the gut matters. Lifestyle matters. The whole body matters.

The microbiome is not static. It changes all the time. So how should one think as a consumer?

I think the most important thing is to be a little more curious and a little less impressed by big numbers on the packaging.

When choosing probiotics:

  • look at which strains the product contains
  • consider what problem you actually want to influence
  • give it time
  • evaluate systematically
  • remember that bacteria work best in an environment that supports them

And perhaps most importantly:

If your stomach reacts negatively, it does not automatically mean that probiotics are “bad.” Sometimes it just means it wasn’t the right tool for your particular situation.

The great thing about the microbiome is that it is malleable. The body is constantly changing in response to how we live. Small things - sleep, food, recovery, nervous system, movement -  affects the environment inside more than many think.

Health is therefore perhaps less about perfection and more about gradually creating better conditions for the body to function as it is meant to.

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Written by

Johanna Holtz

Johanna Holtz är en av våra hälsoexperter och arbetar som klinisk nutritionist med specialisering inom mag- och tarmhälsa samt mikrobiom. Hon hjälper människor att förstå orsaken bakom symtom som IBS, uppblåsthet, hudproblem och trötthet genom individuellt anpassade strategier inom kost och livsstil. Johanna arbetar utifrån ett helhetsperspektiv där tarmen, nervsystemet och resten av kroppen hänger ihop. Läs mer om Johannas arbete på hennes hemsida.